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Atmospheric rivers (ARs) are key agents in distributing extratropical precipitation and transporting moisture poleward. Climate models forced by historical anthropogenic forcing suggest an increase in AR activity in the extratropics over the past four decades. However, reanalyses indicate a ~6° to 10° poleward shift of ARs during boreal winter in both hemispheres, featuring a rise along 50°N and 50°S and a decrease along 30°N and 30°S. Our analysis demonstrates that low-frequency sea surface temperature variability in the tropical eastern Pacific exhibits a cooling tendency since 2000 that plays a key role in driving this global AR shift, mostly over extratropical oceans, through a tropical-driven eddy-mean flow feedback. This mechanism also operates on interannual timescales, controlled by the El Niño–Southern Oscillation, and is less pronounced over the Southern Ocean due to weaker eddy activity during austral summer. These highlight the sensitivity of ARs to large-scale circulation changes driven by both internal variability and external forcing in current and upcoming decades. 

Abstract Nearly half of cancer patients who receive standard-of-care treatments fail to respond to their first-line chemotherapy, demonstrating the pressing need for improved methods to select personalized cancer therapies. Low-coherence digital holography has the potential to fill this need by performing dynamic contrast OCT on living cancer biopsies treated ex vivo with anti-cancer therapeutics. Fluctuation spectroscopy of dynamic light scattering under conditions of holographic phase stability captures ultra-low Doppler frequency shifts down to 10 mHz caused by light scattering from intracellular motions. In the comparative preclinical/clinical trials presented here, a two-species (human and canine) and two-cancer (esophageal carcinoma and B-cell lymphoma) analysis of spectral phenotypes identifies a set of drug response characteristics that span species and cancer type. Spatial heterogeneity across a centimeter-scale patient biopsy sample is assessed by measuring multiple millimeter-scale sub-samples. Improved predictive performance is achieved for chemoresistance profiling by identifying red-shifted sub-samples that may indicate impaired metabolism and removing them from the prediction analysis. These results show potential for using biodynamic imaging for personalized selection of cancer therapy. 

Abstract Directional interactions that generate regular coordination geometries are a powerful means of guiding molecular and colloidal self-assembly, but implementing such high-level interactions with proteins remains challenging due to their complex shapes and intricate interface properties. Here we describe a modular approach to protein nanomaterial design inspired by the rich chemical diversity that can be generated from the small number of atomic valencies. We design protein building blocks using deep learning-based generative tools, incorporating regular coordination geometries and tailorable bonding interactions that enable the assembly of diverse closed and open architectures guided by simple geometric principles. Experimental characterization confirms the successful formation of more than 20 multicomponent polyhedral protein cages, two-dimensional arrays and three-dimensional protein lattices, with a high (10%–50%) success rate and electron microscopy data closely matching the corresponding design models. Due to modularity, individual building blocks can assemble with different partners to generate distinct regular assemblies, resulting in an economy of parts and enabling the construction of reconfigurable networks for designer nanomaterials. 

Abstract. Today's Arctic is characterized by a lengthening of the sea ice melt season, as well as by fast and at times unseasonal melt events. Such anomalous melt cases have been identified in Pacific and Atlantic Arctic sector sea ice studies. Through observational analyses, we document an unprecedented, concurrent marginal ice zone melt event in the Bering Sea and Labrador Sea in March of 2023. Taken independently, variability in the cold-season ice edge at synoptic timescales is common. However, such anomalous, short-term ice loss over either region during the climatological sea ice maxima is uncommon, and the tandem ice loss that occurred qualifies this as a rare event. The atmospheric setting that supported the unseasonal melt events was preceded by a sudden stratospheric warming event amidst background La Niña conditions that led to positive tropospheric height anomalies across much of the Arctic and the development of anomalous mid-troposphere ridges over the ice loss regions. These large-scale anticyclonic centers funneled extremely warm and moist airstreams onto the ice causing melt. Further analysis identified the presence of atmospheric rivers within these warm airstreams whose characteristics likely contributed to this bi-regional ice melt event. Whether such a confluence of anomalous wintertime events associated with troposphere–stratosphere coupling may occur more often in a warming Arctic remains a research area ripe for further exploration. 

Ion transport within saturated porous media is an intricate process in which efficient ion delivery is desired in many engineering problems. However, controlling the behavior of ion transport proves challenging, as ion transport is influenced by a variety of driving mechanisms, which requires a systematic understanding. Herein, we study a coupled advection–diffusion–electromigration system for controlled ion transport within porous media using the scaling analysis. Using the Lattice–Boltzmann–Poisson method, we establish a transport regime classification based on an Advection Diffusion Index (ADI) and a novel Electrodiffusivity Index (EDI) for a two-dimensional (2D) microchannel model under various electric potentials, pressure gradients, and concentration conditions. The resulting transport regimes can be well controlled by changing the applied electric potential, the pressure field, and the injected ions concentration. Furthermore, we conduct numerical simulations in a synthetic 2D porous media and an x-ray microcomputed tomography sandstone image to validate the prevailing transport regime. The simulation results highlight that the defined transport regime observed in our simple micromodel domain is also observed in the synthetic two- and three-dimensional domains, but the boundary between each transport regime differs depending on the variation of the pore size within a given domain. Consequently, the proposed ADI and EDI emerge as dimensionless indicators for controlled ion transport. Overall, our proof-of-concept for ion transport control in porous media is demonstrated under advection–diffusion–electromigration transport, demonstrating the richness of transport regimes that can develop and provide future research directions for subsurface engineering applications. 

Abstract. Today’s Arctic is characterized by a lengthening of the sea ice melt season, but also by fast and at times unseasonal melt events. Such anomalous melt cases have been identified in Pacific and Atlantic Arctic sector sea ice studies. Through observational analyses, we document an unprecedented, simultaneous marginal ice zone melt event in the Bering Sea and Labrador Sea in March of 2023. Taken independently, variability in the cold season ice edge at synoptic time scales is common. However, such anomalous, short-term ice loss over either region during the climatological sea ice maxima is uncommon, and the tandem ice loss that occurred qualifies this as a rare event. The atmospheric setting that supported the unseasonal melt events was preceded by a sudden stratospheric warming event that, along with ongoing La Niña teleconnections, led to positive tropospheric height anomalies across much of the Arctic and the development of anomalous mid-troposphere ridges over the ice loss regions. These large-scale anticyclonic centers funneled extremely warm and moist airstreams onto the ice causing melt. Further analysis identified the presence of atmospheric rivers within these warm airstreams whose characteristics likely contributed to this bi-regional ice melt event. Whether such a confluence of anomalous wintertime events associated with troposphere-stratosphere coupling may occur more often in a warming Arctic remains a research area ripe for further exploration. 

JavaScript has become the most popular programming language for web front-end development. With such popularity, there is a great demand for thorough testing of client-side JavaScript web applications. In this paper, we present a novel approach to concolic testing of front-end JavaScript web applications. This approach leverages widely used JavaScript testing frameworks such as Jest and Puppeteer and conducts concolic execution on JavaScript functions in web applications for unit testing. The seamless integration of concolic testing with these testing frameworks allows injection of symbolic variables within the native execution context of a JavaScript web function and precise capture of concrete execution traces of the function under test. Such concise execution traces greatly improve the effectiveness and efficiency of the subsequent symbolic analysis for test generation. We have implemented our approach on Jest and Puppeteer. The application of our Jest implementation on Metamask, one of the most popular Crypto wallets, has uncovered 3 bugs and 1 test suite improvement, whose bug reports have all been accepted by Metamask developers on Github. We also applied our Puppeteer implementation to 21 Github projects and detected 4 bugs. 

JavaScript (JS) has evolved into a versatile and popular programming language for not only the web, but also a wide range of server-side and client-side applications. Effective, efficient, and easy-to-use testing techniques for JS scripts are in great demand. In this paper, we introduce a holistic approach to applying concolic testing to JS scripts in-situ, i.e., JS scripts are executed in their native environments as part of concolic execution and test cases generated are directly replayed in these environments. We have implemented this approach in the context of Node.js, a JS runtime built on top of Chrome’s V8 JS engine, and evaluated its effectiveness and efficiency through application to 180 Node.js libraries with heavy use of string operations. For 85% of these libraries, it achieved statement coverage ranging between 75% and 100%, a close match in coverage with the hand-crafted unit test suites accompanying their NPM releases. Our approach detected numerous exceptions in these libraries. We analyzed the exception reports for 12 representative libraries and found 6 bugs in these libraries, 4 of which are previously undetected. The bug reports and patches that we filed for these bugs have been accepted by the library developers on GitHub.