Search for: All records

Atmospheric rivers (ARs) are key agents in distributing extratropical precipitation and transporting moisture poleward. Climate models forced by historical anthropogenic forcing suggest an increase in AR activity in the extratropics over the past four decades. However, reanalyses indicate a ~6° to 10° poleward shift of ARs during boreal winter in both hemispheres, featuring a rise along 50°N and 50°S and a decrease along 30°N and 30°S. Our analysis demonstrates that low-frequency sea surface temperature variability in the tropical eastern Pacific exhibits a cooling tendency since 2000 that plays a key role in driving this global AR shift, mostly over extratropical oceans, through a tropical-driven eddy-mean flow feedback. This mechanism also operates on interannual timescales, controlled by the El Niño–Southern Oscillation, and is less pronounced over the Southern Ocean due to weaker eddy activity during austral summer. These highlight the sensitivity of ARs to large-scale circulation changes driven by both internal variability and external forcing in current and upcoming decades. 

Abstract. Today's Arctic is characterized by a lengthening of the sea ice melt season, as well as by fast and at times unseasonal melt events. Such anomalous melt cases have been identified in Pacific and Atlantic Arctic sector sea ice studies. Through observational analyses, we document an unprecedented, concurrent marginal ice zone melt event in the Bering Sea and Labrador Sea in March of 2023. Taken independently, variability in the cold-season ice edge at synoptic timescales is common. However, such anomalous, short-term ice loss over either region during the climatological sea ice maxima is uncommon, and the tandem ice loss that occurred qualifies this as a rare event. The atmospheric setting that supported the unseasonal melt events was preceded by a sudden stratospheric warming event amidst background La Niña conditions that led to positive tropospheric height anomalies across much of the Arctic and the development of anomalous mid-troposphere ridges over the ice loss regions. These large-scale anticyclonic centers funneled extremely warm and moist airstreams onto the ice causing melt. Further analysis identified the presence of atmospheric rivers within these warm airstreams whose characteristics likely contributed to this bi-regional ice melt event. Whether such a confluence of anomalous wintertime events associated with troposphere–stratosphere coupling may occur more often in a warming Arctic remains a research area ripe for further exploration. 

Ion transport within saturated porous media is an intricate process in which efficient ion delivery is desired in many engineering problems. However, controlling the behavior of ion transport proves challenging, as ion transport is influenced by a variety of driving mechanisms, which requires a systematic understanding. Herein, we study a coupled advection–diffusion–electromigration system for controlled ion transport within porous media using the scaling analysis. Using the Lattice–Boltzmann–Poisson method, we establish a transport regime classification based on an Advection Diffusion Index (ADI) and a novel Electrodiffusivity Index (EDI) for a two-dimensional (2D) microchannel model under various electric potentials, pressure gradients, and concentration conditions. The resulting transport regimes can be well controlled by changing the applied electric potential, the pressure field, and the injected ions concentration. Furthermore, we conduct numerical simulations in a synthetic 2D porous media and an x-ray microcomputed tomography sandstone image to validate the prevailing transport regime. The simulation results highlight that the defined transport regime observed in our simple micromodel domain is also observed in the synthetic two- and three-dimensional domains, but the boundary between each transport regime differs depending on the variation of the pore size within a given domain. Consequently, the proposed ADI and EDI emerge as dimensionless indicators for controlled ion transport. Overall, our proof-of-concept for ion transport control in porous media is demonstrated under advection–diffusion–electromigration transport, demonstrating the richness of transport regimes that can develop and provide future research directions for subsurface engineering applications. 

Abstract. Today’s Arctic is characterized by a lengthening of the sea ice melt season, but also by fast and at times unseasonal melt events. Such anomalous melt cases have been identified in Pacific and Atlantic Arctic sector sea ice studies. Through observational analyses, we document an unprecedented, simultaneous marginal ice zone melt event in the Bering Sea and Labrador Sea in March of 2023. Taken independently, variability in the cold season ice edge at synoptic time scales is common. However, such anomalous, short-term ice loss over either region during the climatological sea ice maxima is uncommon, and the tandem ice loss that occurred qualifies this as a rare event. The atmospheric setting that supported the unseasonal melt events was preceded by a sudden stratospheric warming event that, along with ongoing La Niña teleconnections, led to positive tropospheric height anomalies across much of the Arctic and the development of anomalous mid-troposphere ridges over the ice loss regions. These large-scale anticyclonic centers funneled extremely warm and moist airstreams onto the ice causing melt. Further analysis identified the presence of atmospheric rivers within these warm airstreams whose characteristics likely contributed to this bi-regional ice melt event. Whether such a confluence of anomalous wintertime events associated with troposphere-stratosphere coupling may occur more often in a warming Arctic remains a research area ripe for further exploration. 

AbstractElectrokinetic in-situ recovery is an alternative to conventional mining, relying on the application of an electric potential to enhance the subsurface flow of ions. Understanding the pore-scale flow and ion transport under electric potential is essential for petrophysical properties estimation and flow behavior characterization. The governing physics of electrokinetic transport is electromigration and electroosmotic flow, which depend on the electric potential gradient, mineral occurrence, domain morphology (tortuosity and porosity, grain size and distribution, etc.), and electrolyte properties (local pH distribution and lixiviant type and concentration, etc.). Herein, mineral occurrence and its associated zeta potential are investigated for EK transport. The new Ek model which is designed to solve the EK flow in complex porous media in a highly parallelizable manner includes three coupled equations: (1) Poisson equation, (2) Nernst–Planck equation, and (3) Navier–Stokes equation. These equations were solved using the lattice Boltzmann method within X-ray computed microtomography images. The proposed model is validated against COMSOL multiphysics in a two-dimensional microchannel in terms of fluid flow behavior when the electrical double layer is both resolvable and unresolvable. A more complex chalcopyrite-silica system is then obtained by micro-CT scanning to evaluate the model performance. The effects of mineral occurrence, zeta potential, and electric potential on the three-dimensional chalcopyrite-silica system were evaluated. Although the positive zeta potential of chalcopyrite can induce a flow of ferric ion counter to the direction of electromigration, the net effect is dependent on the occurrence of chalcopyrite. However, the ion flux induced by electromigration was the dominant transport mechanism, whereas advection induced by electroosmosis made a lower contribution. Overall, a pore-scale EK model is proposed for direct simulation on pore-scale images. The proposed model can be coupled with other geochemical models for full physicochemical transport simulations. Meanwhile, electrokinetic transport shows promise as a human-controllable technique because the electromigration of ions and the applied electric potential can be easily controlled externally. Graphical abstract 

JavaScript has become the most popular programming language for web front-end development. With such popularity, there is a great demand for thorough testing of client-side JavaScript web applications. In this paper, we present a novel approach to concolic testing of front-end JavaScript web applications. This approach leverages widely used JavaScript testing frameworks such as Jest and Puppeteer and conducts concolic execution on JavaScript functions in web applications for unit testing. The seamless integration of concolic testing with these testing frameworks allows injection of symbolic variables within the native execution context of a JavaScript web function and precise capture of concrete execution traces of the function under test. Such concise execution traces greatly improve the effectiveness and efficiency of the subsequent symbolic analysis for test generation. We have implemented our approach on Jest and Puppeteer. The application of our Jest implementation on Metamask, one of the most popular Crypto wallets, has uncovered 3 bugs and 1 test suite improvement, whose bug reports have all been accepted by Metamask developers on Github. We also applied our Puppeteer implementation to 21 Github projects and detected 4 bugs. 

JavaScript (JS) has evolved into a versatile and popular programming language for not only the web, but also a wide range of server-side and client-side applications. Effective, efficient, and easy-to-use testing techniques for JS scripts are in great demand. In this paper, we introduce a holistic approach to applying concolic testing to JS scripts in-situ, i.e., JS scripts are executed in their native environments as part of concolic execution and test cases generated are directly replayed in these environments. We have implemented this approach in the context of Node.js, a JS runtime built on top of Chrome’s V8 JS engine, and evaluated its effectiveness and efficiency through application to 180 Node.js libraries with heavy use of string operations. For 85% of these libraries, it achieved statement coverage ranging between 75% and 100%, a close match in coverage with the hand-crafted unit test suites accompanying their NPM releases. Our approach detected numerous exceptions in these libraries. We analyzed the exception reports for 12 representative libraries and found 6 bugs in these libraries, 4 of which are previously undetected. The bug reports and patches that we filed for these bugs have been accepted by the library developers on GitHub. 

Abstract Cancer immunotherapy with autologous chimeric antigen receptor (CAR) T cells faces challenges in manufacturing and patient selection that could be avoided by using ‘off-the-shelf’ products, such as allogeneic CAR natural killer T (^AlloCAR-NKT) cells. Previously, we reported a system for differentiating human hematopoietic stem and progenitor cells into^AlloCAR-NKT cells, but the use of three-dimensional culture and xenogeneic feeders precluded its clinical application. Here we describe a clinically guided method to differentiate and expand IL-15-enhanced^AlloCAR-NKT cells with high yield and purity. We generated^AlloCAR-NKT cells targeting seven cancers and, in a multiple myeloma model, demonstrated their antitumor efficacy, expansion and persistence. The cells also selectively depleted immunosuppressive cells in the tumor microenviroment and antagonized tumor immune evasion via triple targeting of CAR, TCR and NK receptors. They exhibited a stable hypoimmunogenic phenotype associated with epigenetic and signaling regulation and did not induce detectable graft versus host disease or cytokine release syndrome. These properties of^AlloCAR-NKT cells support their potential for clinical translation.